2024
A vaccinal strategy based on the use of M2e nanoparticles combined with HA1 domain of hemagglutinin fully protects chickens against challenge with a heterologous highly pathogenic avian influenza H5N1 virus
Calzas C, Alkie T, Suderman M, Embury-Hyatt C, Khatri V, Le Goffic R, Berhane Y, Bourgault S, Archambault D, Chevalier C.
NPJ Vaccines. 2024, Sep 5;9(1):161.
doi: 10.1038/s41541-024-00944-7
PubMed: PMID: 39237609
SARS-CoV2 infection in whole lung primarily targets macrophages that display subset-specific responses.
Vu Manh TP, Gouin C, De Wolf J, Jouneau L, Pascale F, Bevilacqua C, Ar Gouilh M, Da Costa B, Chevalier C, Glorion M, Hannouche L, Urien C, Estephan J, Magnan A, Le Guen M, Marquant Q, Descamps D, Dalod M, Schwartz-Cornil I, Sage E.
Cell Mol Life Sci. 2024 Aug 15;81(1):351.
doi: 10.1007/s00018-024-05322-z.
PubMed: PMID: 39147987
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Sake SM, Zhang X, Rajak MK, Urbanek-Quaing M, Carpentier A, Gunesch AP, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee AK, Johnson K, Morwood K, Rox K, Elgaher WAM, Huang J, Wetzke M, Hansen G, Fischer N, Eléouët JF, Rameix-Welti MA, Hirsch AKH, Herold E, Empting M, Lauber C, Schulz TF, Krey T, Haid S, Pietschmann T.
Nat Commun. 2024 Feb 8;15(1):1173.
doi: 10.1038/s41467-024-45241-y.
PubMed: PMID: 38332002
2023
Infection with Influenzavirus A in a murine model induces epithelial bronchial lesions and distinct waves of innate immune-cell recruitment
Rivière F, Burger J, Lefèvre F, Garnier A, Vigne C, Tournier JN, Billon-Denis E.
Front. Immunol. 2023 Aug 15:14:1241323.
doi: 10.3389/fimmu.2023.1241323
PubMed: PMID: 37649477
Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion
Franzi E, Mathez G, Dinant S, Deloizy C, Kaiser L Tapparel C, Le Goffic R, Cagno V.
Int J Mol Sci. 2023 Oct 19;24(20):15382.
doi: 10.3390/ijms242015382.
PubMed: PMID: 37895062
Editorial: New-generation vaccines and novel vaccinal strategies against infectious diseases of livestock, wild and companion animals.
Pickering B, Manzano-Román R, Tikoo SK, Chevalier C, Archambault D
Front Immunol. 2023 Aug 2;14:1256363.
doi: 10.3389/fimmu.2023.1256363
PubMed: PMID: 37600777
Cell type- and time-dependent biological responses in ex vivo perfused lung grafts.
Gouin C, Vu Manh TP, Jouneau L, Bevilacqua C, De Wolf J, Glorion M, Hannouche L, Urien C, Estephan J, Roux A, Magnan A, Le Guen M, Da Costa B, Chevalier C, Descamps D, Schwartz-Cornil I, Dalod M, Sage E.
Front Immunol. 2023 Jul 3;14:1142228.
doi: 10.3389/fimmu.2023.1142228
PubMed: PMID: 37465668
Comparison of PB1-F2 Proximity Interactomes Reveals Functional Differences between a Human and an Avian Influenza Virus.
Mettier J, Prompt C, Bruder E, Da Costa B, Chevalier C, Le Goffic R.
Viruses. 2023 Jan 24;15(2):328.
doi: 10.3390/v15020328.
PubMed: PMID: 36851542
An Isolate of Streptococcus mitis Displayed In Vitro Antimicrobial Activity and Deleterious Effect in a Preclinical Model of Lung Infection.
Mathieu E, Marquant Q, Chain F, Bouguyon E, Saint-Criq V, Le Goffic R, Descamps D, Langella P, Tompkins TA, Binda S, Thomas M.
Nutrients. 2023 Jan 4;15(2):263.
doi: 10.3390/nu15020263
PubMed: PMID: 36678133
2022
Host succinate inhibits influenza virus infection through succinylation and nuclear retention of the viral nucleoprotein.
Guillon A, Brea-Diakite D, Cezard A, Wacquiez A, Baranek T, Bourgeais J, Picou F, Vasseur V, Meyer L, Chevalier C, Auvet A, Carballido JM, Nadal Desbarats L, Dingli F, Turtoi A, Le Gouellec A, Fauvelle F, Donchet A, Crépin T, Hiemstra PS, Paget C, Loew D, Herault O, Naffakh N, Le Goffic R, Si-Tahar M.
EMBO J. 2022 May 4:e108306.
doi: 10.15252/embj.2021108306.
PubMed: PMID: 35506364
2021
Influenza viruses and coronaviruses: Knowns, unknowns, and common research challenges.
Terrier O, Si-Tahar M, Ducatez M, Chevalier C, Pizzorno A, Le Goffic R, Crépin T, Simon G, Naffakh N.
PLoS Pathog. 2021 Dec 30;17(12):e1010106.
doi: 10.1371/journal.ppat.1010106.
PubMed: PMID: 34969061
Immunogenicity and Protective Potential of Mucosal Vaccine Formulations Based on Conserved Epitopes of Influenza A Viruses Fused to an Innovative Ring Nanoplatform in Mice and Chickens.
Calzas C, Mao M, Turpaud M, Viboud Q, Mettier J, Figueroa T, Bessière P, Mangin A, Sedano L, Hervé PL, Volmer R, Ducatez MF, Bourgault S, Archambault D, Le Goffic R, Chevalier C.
Front Immunol. 2021 Nov 11;12:772550.
doi: 10.3389/fimmu.2021.772550.
PubMed: PMID: 34868036
A condensate-hardening drug blocks RSV replication in vivo.
Risso-Ballester J, Galloux M, Cao J, Le Goffic R, Hontonnou F, Jobart-Malfait A, Desquesnes A, Sake SM, Haid S, Du M, Zhang X, Zhang H, Wang Z, Rincheval V, Zhang Y, Pietschmann T, Eléouët JF, Rameix-Welti MA, Altmeyer R.
Nature. 2021 Jul;595(7868):596-599.
doi: 10.1038/s41586-021-03703-z.
PubMed: PMID: 34234347
PB1-F2 amyloid-like fibers correlate with proinflammatory signaling and respiratory distress in influenza-infected mice.
Chevalier C, Leymarie O, Sedano L, Da Costa B, Richard CA, Maisonnasse P, Réfregiers M, Jamme F, Le Goffic R.
J Biol Chem. 2021 Jul;297(1):100885.
doi: 10.1016/j.jbc.2021.100885.
PubMed: PMID: 34146545
Study of the host specificity of PB1-F2-associated virulence.
Mettier J, Marc D, Sedano L, Da Costa B, Chevalier C, Le Goffic R.
Virulence. 2021 Dec;12(1):1647-1660.
doi: 10.1080/21505594.2021.1933848.
PubMed: PMID: 34125653
Influenza Virus Infection Impairs the Gut's Barrier Properties and Favors Secondary Enteric Bacterial Infection through Reduced Production of Short-Chain Fatty Acids.
Sencio V, Gallerand A, Gomes Machado M, Deruyter L, Heumel S, Soulard D, Barthelemy J, Cuinat C, Vieira AT, Barthelemy A, Tavares LP, Guinamard R, Ivanov S, Grangette C, Teixeira MM, Foligné B, Wolowczuk I, Le Goffic R, Thomas M, Trottein F.
Infect Immun. 2021 Aug 16;89(9):e0073420.
doi: 10.1128/IAI.00734-20.
PubMed: PMID: 33820816
Low Doses of Radiation Increase the Immunosuppressive Profile of Lung Macrophages During Viral Infection and Pneumonia.
Meziani L, Robert C, Classe M, Da Costa B, Mondini M, Clémenson C, Alfaro A, Mordant P, Ammari S, Le Goffic R, Deutsch E.
Int J Radiat Oncol Biol Phys. 2021 Aug 1;110(5):1283-1294.
doi: 10.1016/j.ijrobp.2021.03.022.
PubMed: PMID: 33722770
Self-assembled peptide nanorod vaccine confers protection against influenza A virus.
Zottig X, Al-Halifa S, Côté-Cyr M, Calzas C, Le Goffic R, Chevalier C, Archambault D, Bourgault S.
Biomaterials. 2021 Feb;269:120672.
doi: 10.1016/j.biomaterials.2021.120672.
PubMed: PMID: 33476893
2020
Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo.
Kocabiyik O, Cagno V, Silva PJ, Zhu Y, Sedano L, Bhide Y, Mettier J, Medaglia C, Da Costa B, Constant S, Huang S, Kaiser L, Hinrichs WLJ, Huckriede A, Le Goffic R, Tapparel C, Stellacci F.
Adv Sci (Weinh). 2020 Dec 14;8(3):2001012.
doi: 10.1002/advs.202001012.
PubMed: PMID: 33552848
Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection.
Pålsson SA, Dondalska A, Bergenstråhle J, Rolfes C, Björk A, Sedano L, Power UF, Rameix-Welti MA, Lundeberg J, Wahren-Herlenius M, Mastrangelo P, Eleouet JF, Le Goffic R, Galloux M, Spetz AL.
Front Immunol. 2020 Dec 8;11:580547.
doi: 10.3389/fimmu.2020.580547.
PubMed: PMID: 33363532
Targeting the Respiratory Syncytial Virus N0-P Complex with Constrained α-Helical Peptides in Cells and Mice.
Galloux M, Gsponer N, Gaillard V, Fenner B, Larcher T, Vilotte M, Rivière J, Richard CA, Eléouët JF, Le Goffic R, Mettier J, Nyanguile O.
Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00717-20.
doi: 10.1128/AAC.00717-20.
PubMed: PMID: 32660994
Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters.
Bryche B, St Albin A, Murri S, Lacôte S, Pulido C, Ar Gouilh M, Lesellier S, Servat A, Wasniewski M, Picard-Meyer E, Monchatre-Leroy E, Volmer R, Rampin O, Le Goffic R, Marianneau P, Meunier N.
Brain Behav Immun. 2020 Oct;89:579-586.
doi: 10.1016/j.bbi.2020.06.032.
PubMed: PMID: 32629042
Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues.
Ayari A, Rosa-Calatrava M, Lancel S, Barthelemy J, Pizzorno A, Mayeuf-Louchart A, Baron M, Hot D, Deruyter L, Soulard D, Julien T, Faveeuw C, Molendi-Coste O, Dombrowicz D, Sedano L, Sencio V, Le Goffic R, Trottein F, Wolowczuk I.
Commun Biol. 2020 May 14;3(1):237.
doi: 10.1038/s42003-020-0965-6.
PubMed: PMID: 32409640
Labyrinthopeptins as virolytic inhibitors of respiratory syncytial virus cell entry.
Blockus S, Sake SM, Wetzke M, Grethe C, Graalmann T, Pils M, Le Goffic R, Galloux M, Prochnow H, Rox K, Hüttel S, Rupcic Z, Wiegmann B, Dijkman R, Rameix-Welti MA, Eléouët JF, Duprex WP, Thiel V, Hansen G, Brönstrup M, Haid S, Pietschmann T.
Antiviral Res. 2020 May;177:104774.
doi: 10.1016/j.antiviral.2020.104774.
PubMed: PMID: 32197980
2019
Impact of the influenza protein PB1-F2 on the biochemical composition of human epithelial cells revealed by synchrotron Fourier transform infrared spectromicroscopy.
Leymarie, O. Le Goffic, R. Jamme, F. Chevalier, C.
Journal of Spectral Imaging 2019, 8 (1), a18.
doi: 10.1255/jsi.2019.a18
Editorial: Innovative Therapeutic and Vaccine Approaches Against Respiratory Pathogens.
Calzas, C. Descamps, D. Chignard, M. Chevalier, C.
Front Immunol 2019, 10, 2960.
doi: 10.3389/fimmu.2019.02960
PubMed: PMID: 31921201
Innovative Mucosal Vaccine Formulations Against Influenza A Virus Infections.
Calzas, C. Chevalier, C.
Front Immunol 2019, 10, 1605.
doi: 10.3389/fimmu.2019.01605
PubMed: PMID: 31379823
2018
Interleukin-22 Immunotherapy during Severe Influenza Enhances Lung Tissue Integrity and Reduces Secondary Bacterial Systemic Invasion.
Barthelemy A, Sencio V, Soulard D, Deruyter L, Faveeuw C, Le Goffic R, Trottein F.
Infect Immun. 2018 Jun 21;86(7):e00706-17.
doi: 10.1128/IAI.00706-17
PubMed: PMID: 29661933
Humoral Responses Elicited by Adenovirus Displaying Epitopes Are Induced Independently of the Infection Process and Shaped by the Toll-Like Receptor/MyD88 Pathway.
Anchim A, Raddi N, Zig L, Perrieau P, Le Goffic R, Ryffel B, Benihoud K.
Front Immunol. 2018 Feb 5;9:124.
doi: 10.3389/fimmu.2018.00124
PubMed: PMID: 29459860
Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism.
Cagno V, Andreozzi P, D'Alicarnasso M, Jacob Silva P, Mueller M, Galloux M, Le Goffic R, Jones ST, Vallino M, Hodek J, Weber J, Sen S, Janeček ER, Bekdemir A, Sanavio B, Martinelli C, Donalisio M, Rameix Welti MA, Eleouet JF, Han Y, Kaiser L, Vukovic L, Tapparel C, Král P, Krol S, Lembo D, Stellacci F.
Nat Mater. 2018 Feb;17(2):195-203.
doi: 10.1038/nmat5053
PubMed: PMID: 29251725
